tmb-msi-calculator
// Tumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
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updated:March 4, 2026
SKILL.mdreadonly
SKILL.md Frontmatter
nametmb-msi-calculator
descriptionTumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
allowed-toolsRead,Write,Glob,Grep,Edit,WebFetch,WebSearch,Bash
metadata[object Object]
TMB-MSI Calculator Skill
Purpose
Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment.
Capabilities
- TMB calculation from VCF
- MSI status determination
- Neoantigen prediction
- HLA typing integration
- Biomarker thresholds
- Clinical report generation
Usage Guidelines
- Calculate TMB with appropriate normalization
- Determine MSI status accurately
- Predict neoantigens for immunotherapy
- Apply clinical thresholds for reporting
- Generate actionable reports
- Document methodology and thresholds
Dependencies
- TMBcat
- MSIsensor2
- MANTIS
Process Integration
- Tumor Molecular Profiling (tumor-molecular-profiling)