adaptyv

Adaptyv

Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or web interface and receive experimental results in approximately 21 days.

Quick Start

Authentication Setup

Adaptyv requires API authentication. Set up your credentials:

1. Contact support@adaptyvbio.com to request API access (platform is in alpha/beta)
2. Receive your API access token
3. Set environment variable:

export ADAPTYV_API_KEY="your_api_key_here"

Or create a .env file:

ADAPTYV_API_KEY=your_api_key_here

Installation

Install the required package using uv:

uv pip install requests python-dotenv

Basic Usage

Submit protein sequences for testing:

import os
import requests
from dotenv import load_dotenv

load_dotenv()

api_key = os.getenv("ADAPTYV_API_KEY")
base_url = "https://kq5jp7qj7wdqklhsxmovkzn4l40obksv.lambda-url.eu-central-1.on.aws"

headers = {
    "Authorization": f"Bearer {api_key}",
    "Content-Type": "application/json"
}

# Submit experiment
response = requests.post(
    f"{base_url}/experiments",
    headers=headers,
    json={
        "sequences": ">protein1\nMKVLWALLGLLGAA...",
        "experiment_type": "binding",
        "webhook_url": "https://your-webhook.com/callback"
    }
)

experiment_id = response.json()["experiment_id"]

Available Experiment Types

Adaptyv supports multiple assay types:

• Binding assays - Test protein-target interactions using biolayer interferometry
• Expression testing - Measure protein expression levels
• Thermostability - Characterize protein thermal stability
• Enzyme activity - Assess enzymatic function

See reference/experiments.md for detailed information on each experiment type and workflows.

Protein Sequence Optimization

Before submitting sequences, optimize them for better expression and stability:

Common issues to address:

• Unpaired cysteines that create unwanted disulfides
• Excessive hydrophobic regions causing aggregation
• Poor solubility predictions

Recommended tools:

• NetSolP / SoluProt - Initial solubility filtering
• SolubleMPNN - Sequence redesign for improved solubility
• ESM - Sequence likelihood scoring
• ipTM - Interface stability assessment
• pSAE - Hydrophobic exposure quantification

See reference/protein_optimization.md for detailed optimization workflows and tool usage.