DLS Particle Sizer

Purpose

The DLS Particle Sizer skill provides dynamic light scattering analysis for nanoparticle hydrodynamic size determination, enabling rapid, non-destructive measurement of size distributions and stability assessment.

Capabilities

• Hydrodynamic diameter measurement
• Polydispersity index (PDI) calculation
• Size distribution analysis (intensity, volume, number)
• Temperature-dependent measurements
• Multi-angle DLS analysis
• Particle concentration estimation

Usage Guidelines

DLS Measurement

1. Sample Preparation

   • Dilute to appropriate concentration
   • Filter to remove dust
   • Equilibrate temperature

2. Data Analysis

   • Use cumulants for monomodal samples
   • Apply CONTIN for multimodal
   • Report intensity-weighted Z-average

3. Quality Metrics

   • PDI < 0.1: Monodisperse
   • PDI 0.1-0.3: Narrow distribution
   • PDI > 0.3: Broad distribution

Process Integration

• Statistical Particle Size Distribution Analysis
• Nanoparticle Synthesis Protocol Development
• Nanoparticle Drug Delivery System Development

Input Schema

{
  "sample_id": "string",
  "solvent": "string",
  "temperature": "number (C)",
  "refractive_index": "number",
  "viscosity": "number (cP)"
}

Output Schema

{
  "z_average": "number (nm)",
  "pdi": "number",
  "distribution": {
    "intensity": {"peaks": [{"size": "number", "percent": "number"}]},
    "volume": {"peaks": [{"size": "number", "percent": "number"}]},
    "number": {"peaks": [{"size": "number", "percent": "number"}]}
  },
  "quality_metrics": {
    "intercept": "number",
    "baseline": "number"
  }
}