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clinvar-querier

// ClinVar database query skill for clinical variant interpretation and pathogenicity lookup

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stars:384
forks:73
updated:March 4, 2026
SKILL.mdreadonly
SKILL.md Frontmatter
nameclinvar-querier
descriptionClinVar database query skill for clinical variant interpretation and pathogenicity lookup
allowed-toolsRead,Write,Glob,Grep,Edit,WebFetch,WebSearch,Bash
metadata[object Object]

ClinVar Querier Skill

Purpose

Enable ClinVar database queries for clinical variant interpretation and pathogenicity lookup.

Capabilities

  • Variant significance lookup
  • Submission history retrieval
  • Condition association queries
  • Evidence level assessment
  • Batch variant queries
  • VCF annotation integration

Usage Guidelines

  • Query variants with standard nomenclature
  • Review submission history for context
  • Consider evidence levels in interpretation
  • Batch query for efficiency
  • Integrate with VCF annotation
  • Document ClinVar version dates

Dependencies

  • ClinVar API
  • VarSome API
  • OMIM

Process Integration

  • Clinical Variant Interpretation (clinical-variant-interpretation)
  • Rare Disease Diagnostic Pipeline (rare-disease-diagnostics)
  • Tumor Molecular Profiling (tumor-molecular-profiling)